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TAJRIBA HAYVONLARIDA BRUTSELLYOZ QO‘ZG‘ATUVCHILARIGA QARSHI IJOBIY STANDART POLIVALENT ZARDOBLARNI OLISH
Maqola haqida umumiy ma'lumotlar
Maqolada brutselloz infeksiyasini erta tashxislash va serologik usullarni takomillashtirish maqsadida brutselloz qo‘zg‘atuvchilariga qarshi standart polivalent zardob olish bo‘yicha olib borilgan tajribaviy tadqiqotlar natijalari bayon etilgan. Tadqiqotda 12 ta quyon 4 guruhga bo‘linib, ularga turli immunizatsiya sxemalari asosida B. abortus 19 tirik vaksinasi va faolsizlantirilgan brutsella kulturasi suspenziyalari turli konsentratsiyalarda yuborilgan. Olingan zardoblarda umumiy oqsil, albumin, globulin, IgA, IgM va IgG miqdorlari aniqlanib, ularning immun javob shakllanishidagi o‘zgarish dinamikasi baholangan. Tadqiqot natijalariga ko‘ra, tirik, virulentligi pasaytirilgan B. abortus 19 vaksinasi bilan immunizatsiya qilinganda barqaror va davomli immun javob shakllanganligi, to‘liq bo‘lmagan Freynd ad’yuvanti qo‘llanilganda esa immunoglobulinlar darajasi yanada yuqori bo‘lganligi aniqlangan. Olingan natijalar asosida milliy standart zardob tayyorlashning ilmiy-amaliy asoslari ishlab chiqildi. Ushbu zardob brutsellozning serologik diagnostikasini standartlashtirish, diagnostikumlar sifatini nazorat qilish hamda xalqaro miqyosda solishtiriladigan natijalarni ta’minlash imkonini beradi.
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