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СИРОЛИМУС КАК НОВАЯ ТЕРАПЕВТИЧЕСКАЯ ОПЦИЯ ПРИ РЕЗИСТЕНТНЫХ СОСУДИСТЫХ МАЛЬФОРМАЦИЯХ У ДЕТЕЙ
Общая информация о статье
Сосудистые аномалии являются одной из сложных патологий в педиатрической практике. Классические методы лечения — склеротерапия, хирургическая резекция, пропранолол и стероиды — часто не дают полного эффекта и значительно ограничивают качество жизни пациентов. В последние годы сиролимус, ингибитор пути mTOR, рассматривается как перспективный препарат для лечения сложных и резистентных сосудистых аномалий.
- Wassef M, Blei F, Adams D, et al. Vascular anomalies classification: recommendations from the ISSVA. Pediatrics. 2015;136(1):e203-e214.
- Yesil S, Tanyildiz HG, Bozkurt C, et al. Single-center experience with sirolimus therapy for vascular malformations. Pediatr Hematol Oncol. 2016;33(4):219-225.
- Triana P, Dore M, Cerezo VN, et al. Sirolimus in the treatment of vascular anomalies. Eur J Pediatr Surg. 2017;27(1):86-90.
- Lackner H, Karastaneva A, Schwinger W, et al. Sirolimus for the treatment of children with various complicated vascular anomalies. Eur J Pediatr. 2015;174(12):1579-1584.
- Adams DM, Trenor CC Ⅲ, Hammill AM, et al. Efficacy and safety of sirolimus in the treatment of complicated vascular anomalies. Pediatrics. 2016;137(2):e20153257.
- Goldenberg DC, Carvas M, Adams D, et al. Successful treatment of a complex vascular malformation with sirolimus and surgical resection. J Pediatr Hematol Oncol. 2017;39(3):e191-e195.
- Strychowsky JE, Rahbar R, O’Hare MJ, et al. Sirolimus as treatment for 19 patients with refractory cervicofacial lymphatic malformation. Laryngoscope. 2018;128(2):269-276.
- Freixo C, Ferreira V, Martins J, et al. Efficacy and safety of sirolimus in the treatment of vascular anomalies: a systematic review. J Vasc Surg. 2020;71(1):318-327.
- Durand R, et al. MRI assessment for response to sirolimus in extensive lymphatic malformations in children. AJR Am J Roentgenol. 2021;217(4):873-880.
- Maruani A, et al. Sirolimus (Rapamycin) for slow-flow malformations in children: the PERFORMUS trial. JAMA Dermatol. 2021;157(11):1289-1298.
- Durán-Romero AJ, Hernández-Rodríguez JC, Ortiz-Álvarez J, et al. Efficacy of oral sirolimus for high-flow vascular malformations in real practice. Clin Exp Dermatol. 2022;47(1):57-62.
- Saibene AM, et al. Sirolimus treatment for paediatric head and neck lymphatic malformations: a systematic review. Front Pediatr. 2023;11:10313583.
- Seront E, et al. VASE trial: sirolimus in slow-flow vascular malformations. JCI Insight. 2023;8(21):e173095.
- Ozeki M, et al. Sirolimus treatment for intractable lymphatic anomalies (SILA study). Front Med (Lausanne). 2024;11:1335469.
- Park J, Ha S, Kwon H, et al. Sirolimus for complicated vascular anomalies: a single-center 2-year experience. Ann Pediatr Surg. 2024;30(1):14-21.
- Wang J, et al. Sirolimus in the treatment of pediatric lymphatic malformations: a real-world study. Int J Pediatr Otorhinolaryngol. 2024;174:111518.
- Wang G, et al. Effectiveness and safety of sirolimus in the treatment of venous malformations. J Vasc Surg Venous Lymphat Disord. 2025;13(2):e00096-e00105.
- Nisbet R, et al. Oral sirolimus therapy for complex low-flow vascular malformations. J Vasc Surg Venous Lymphat Disord. 2025;15(2):e00096-e00105.
- Alomari AI, Fishman SJ, Burrows PE, et al. Combined embolization and sirolimus for complex vascular anomalies. Pediatr Radiol. 2019;49(12):1654-1663.
- Hammill AM, Wentzel M, Gupta A, et al. Sirolimus for maintenance therapy in pediatric vascular anomalies. Pediatr Blood Cancer. 2019;66(12):e27954.
- Shaikh R, et al. Long-term sirolimus therapy for refractory vascular malformations in children. Pediatr Surg Int. 2020;36(10):1125-1133.
- Alqahtani A, et al. Sirolimus treatment outcomes in lymphangiomas: experience from a tertiary center. World J Pediatr Surg. 2020;3:e000113.
- Kim DW, et al. Sirolimus therapy for lymphatic malformations: clinical and radiologic outcomes. Korean J Pediatr. 2021;64(5):217-224.
- Donnelly LF, et al. Imaging response patterns in children with vascular anomalies treated with sirolimus. Pediatr Radiol. 2021;51(11):1973-1981.
- Horbach SER, et al. Sirolimus for complex slow-flow vascular malformations: an international cohort study. Orphanet J Rare Dis. 2022;17:89.
- Elluru RG, et al. Role of sirolimus in airway lymphatic malformations: a multicenter review. Int J Pediatr Otorhinolaryngol. 2022;159:111229.
- Wu JK, et al. Clinical and genetic predictors of response to sirolimus in vascular malformations. Hum Genet. 2022;141(12):1959-1970.
- Perkins JA, et al. Pediatric lymphatic malformations and sirolimus: 5-year outcomes. Laryngoscope. 2023;133(4):892-900.
- Tang Y, et al. Sirolimus improves quality of life in children with cervicofacial lymphatic malformations. Eur J Pediatr. 2023;182(6):2475-2483.
- Zhang H, et al. Efficacy and safety of sirolimus in complex vascular malformations: a multicenter prospective study. Orphanet J Rare Dis. 2024;19:211.
- Xu Q, et al. Low-dose sirolimus in pediatric vascular anomalies: a prospective clinical trial. Front Pharmacol. 2024;15:1378429.
, С. ., , С. ., & , К. . (2025). СИРОЛИМУС КАК НОВАЯ ТЕРАПЕВТИЧЕСКАЯ ОПЦИЯ ПРИ РЕЗИСТЕНТНЫХ СОСУДИСТЫХ МАЛЬФОРМАЦИЯХ У ДЕТЕЙ. ALFRAGANUS, (4), 99–108. https://doi.org/
, САДЫКОВ Р.Р., et al. “СИРОЛИМУС КАК НОВАЯ ТЕРАПЕВТИЧЕСКАЯ ОПЦИЯ ПРИ РЕЗИСТЕНТНЫХ СОСУДИСТЫХ МАЛЬФОРМАЦИЯХ У ДЕТЕЙ.” Academic Research in Educational Sciences, vol. 4, no. , 2025, pp. 99–108, https://doi.org/.
, ., , ., and , . 2025. СИРОЛИМУС КАК НОВАЯ ТЕРАПЕВТИЧЕСКАЯ ОПЦИЯ ПРИ РЕЗИСТЕНТНЫХ СОСУДИСТЫХ МАЛЬФОРМАЦИЯХ У ДЕТЕЙ. Academic Research in Educational Sciences. 4(), pp.99–108.