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SURUNKALI YURAK ETISHMOVCHILIGI BILAN HASTALANGAN BEMORLARINING QON PLAZMASIDA FUROSEMIDNI ANIQLASH
General information about the article
Furosemide is a powerful diuretic drug that is widely used to treat various diseases, including patients with chronic heart failure (CHF). In some cases, furosemide causes side effects such as hypokalemia and heart rhythm disturbances. A method has been developed to determine the concentration of the drug in the blood to prevent furosemide poisoning and assess its therapeutic effect. High-performance liquid chromatography (HPLC) was used. Furosemide was extracted from blood serum with ethyl acetate to isolate it. The resulting extracts were dissolved in a mobile phase, a mixture of acetonitrile and 1% acetic acid (30:70), and chromatographed. Furosemide retention time on the chromatogram was 4.3 minutes. Blood samples from patients with chronic heart failure were collected at intervals of 2, 4, and 6 hours. The results showed that the developed method is suitable for therapeutic monitoring of furosemide during treatment of patients with CHF.
1. ЮнусходжаевА.Н., ШаисломовБ.Ш., АлиходжаеваМ.И. Осложнения лекарственной терапии./ Изд. «Fanvatexnologiya», - 2014.- 356 с.
https://e-library.sammu.uz/ru/book/1238
2. Patel R, Patel P, Patel N, Gangwani J, Patel D, Case report on the interaction between furo-semide and digoxin that caused digoxin toxicity. Journal of Drug Delivery and Therapeutics. 2022; 12(5-S):9-12 DOI: http://dx.doi.org/10.22270/jddt.v12i5-s.5717
3. Алиходжаева, М. И., & Попков, В. А. (2008). Физико-химическое и химико-токсикологическое исследование некоторых диуретических лекарственных средств. Изд. Московского университета.
4. Alikhodjaeva, M., Atahanov, A., &Xamdamov, M. (2015). Development of Methodology for the Isolation and Determination of Propafenone in Blood Samples via HPLC. Journalof US-ChinaMedicalScience, 12, 163-171.
https://www.semanticscholar.org/paper/Development-of-Methodology-for-the-Isolation-and-of-Madina-Alikhodjaeva/b45a901ec565f0bcff51660f17caa0cf66d3727c?p2df
5. Алиходжаева, М. И., Симонов, Е. А., Киричёк, А. В., & Попков, В. А. (2009). Хромато-масс-спектрометрическое определение некоторых диуретиков в биологических жидко-стях. Судебно-медицинская экспертиза, 52(5), 27-29.
https://elibrary.ru/item.asp?id=13072746
6. Алиходжаева, М. И., & Попков, В. А. (2009). Экспресс-анализ некоторых диуретиков в биологических жидкостях. Фармация Казахстана.-Алматы, 1, 27-28.
7. Алиходжаева, М. И. (2009). Исследование некоторых синтетических диуретиков ме-тодом термодесорбционной поверхностно-ионизационной спектроскопии. Вопросы биоло-гической, медицинской и фармацевтической химии, (1), 61-63.
Alikhodjaeva, M. I., & Mustanov, T. B. (2025). SURUNKALI YURAK ETISHMOVCHILIGI BILAN HASTALANGAN BEMORLARINING QON PLAZMASIDA FUROSEMIDNI ANIQLASH. ALFRAGANUS, (4), 55–60. https://doi.org/
Alikhodjaeva, Madina, and Tolib Mustanov,. “SURUNKALI YURAK ETISHMOVCHILIGI BILAN HASTALANGAN BEMORLARINING QON PLAZMASIDA FUROSEMIDNI ANIQLASH.” Academic Research in Educational Sciences, vol. 4, no. , 2025, pp. 55–60, https://doi.org/.
Alikhodjaeva, I. and Mustanov, B. 2025. SURUNKALI YURAK ETISHMOVCHILIGI BILAN HASTALANGAN BEMORLARINING QON PLAZMASIDA FUROSEMIDNI ANIQLASH. Academic Research in Educational Sciences. 4(), pp.55–60.